Safety factors publications

Abstract In chemical risk assessment for many substances only short-term animal studies are available for the evaluation of long-term human exposure. Therefore usually extrapolation factors (EF) are…

Abstract Repeated dose toxicity studies from the RepDose database (DB) were used to determine interspecies differences for rats and mice. NOEL (no observed effect level) ratios based on systemic…

aim The aim of the project is to assess time and interspecies extrapolation factors based on a solid databasis using the Fraunhofer database RepDose (www.fraunhofer-repdose.de)

Introduction • Route to Route extrapolation (R2R) is required if no in vivo data on the appropriate route are available• R2R needs to be performed in a case by case approach for the individual…

Abstract Human health risk assessment of chemicals requires solid information on adverse effects after long-term exposure. Because of ethical considerations, human data or even long-term studies…

Introduction EUROTOX 2014, 7th – 10th September 2014, Edinburgh International Conference Centre In human risk assessment any relevant exposure route (oral, inhalation and dermal) has to be…

Introduction In regulatory risk assessment, extrapolation factors (EFs) are used to extrapolate from experimental conditions (animal studies) to human exposure.Time extrapolation: a short time study…

Abstract In risk assessment time extrapolationfactors (EFs) are used when a short time study is available, but chronic exposure needs to be considered.Probabilistic analyses are needed to…