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Safety factors publications
Evaluation of time extrapolation factors based on the database RepDose
May 2011
Nicolas Stockreiter
Safety factors publications
Abstract
In chemical risk assessment for many substances only short-term animal studies are available for the evaluation of long-term human exposure. Therefore usually extrapolation factors (EF) are…
Author:
M. Batke et al.
Doc type:
Article 8 pages
Downloads
4051
Interspecies extrapolation based on the RepDose database—A probabilistic approach
January 2013
Nicolas Stockreiter
Safety factors publications
Abstract
Repeated dose toxicity studies from the RepDose database (DB) were used to determine interspecies differences for rats and mice. NOEL (no observed effect level) ratios based on systemic…
Author:
S. Escher et al.
Doc type:
Article 7 pages
Downloads
3572
Evaluation of risk assessment factors for interspecies an dtime-extrapolation
January 0001
Nicolas Stockreiter
Safety factors publications
aim
The aim of the project is to assess time and interspecies extrapolation factors based on a solid databasis using the Fraunhofer database RepDose (www.fraunhofer-repdose.de)
Author:
S.Escher et al.
Doc type:
One pager
Downloads
3800
Sound oral to inhalation extrapolation factors (EFs) for human health risk assessment
January 0001
Nicolas Stockreiter
Safety factors publications
Introduction
• Route to Route extrapolation (R2R) is required if no in vivo data on the appropriate route are available• R2R needs to be performed in a case by case approach for the individual…
Author:
M.Batke et al.
Doc type:
One Pager
Downloads
3862
Assessment factors in human health risk assessment and their associated level of safety
January 0001
Nicolas Stockreiter
Safety factors publications
Abstract
Human health risk assessment of chemicals requires solid information on adverse effects after long-term exposure. Because of ethical considerations, human data or even long-term studies…
Author:
S. Escher et al.
Doc type:
Poster
Downloads
3874
Route to Route Extrapolation Factors for Regulatory Risk Assessment – a Probabilistic Approach
September 2014
Nicolas Stockreiter
Safety factors publications
Introduction
EUROTOX 2014, 7th – 10th September 2014, Edinburgh International Conference Centre In human risk assessment any relevant exposure route (oral, inhalation and dermal) has to be…
Author:
K. Schröder et al.
Doc type:
One Pager
Downloads
4343
Update of time extrapolation factors for risk assessment –the benefit of combined databases and probabilistic analyses
January 0001
Nicolas Stockreiter
Safety factors publications
Introduction
In regulatory risk assessment, extrapolation factors (EFs) are used to extrapolate from experimental conditions (animal studies) to human exposure.Time extrapolation: a short time study…
Author:
S. Escher et al.
Doc type:
One pager
Downloads
3771
Time extrapolation factors for risk assessment: are group specific extrapolation factors possible? (eTOXV)
January 0001
Nicolas Stockreiter
Safety factors publications
Abstract
In risk assessment time extrapolationfactors (EFs) are used when a short time study is available, but chronic exposure needs to be considered.Probabilistic analyses are needed to…
Author:
S. Escher et al.
Doc type:
One pager
Downloads
4007
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