Human health SAFETY FACTORS PROJECT

Safety factors publications

Evaluation of time extrapolation factors based on the database RepDose

Abstract In chemical risk assessment for many substances only short-term animal studies are available for the evaluation of long-term human exposure. Therefore usually extrapolation factors (EF) are…
  • Author:
    M. Batke et al.
  • Doc type:
    Article 8 pages
  • Downloads
    4687
Interspecies extrapolation based on the RepDose database—A probabilistic approach

Abstract Repeated dose toxicity studies from the RepDose database (DB) were used to determine interspecies differences for rats and mice. NOEL (no observed effect level) ratios based on systemic…
  • Author:
    S. Escher et al.
  • Doc type:
    Article 7 pages
  • Downloads
    4298
Evaluation of risk assessment factors for interspecies an dtime-extrapolation

aim The aim of the project is to assess time and interspecies extrapolation factors based on a solid databasis using the Fraunhofer database RepDose (www.fraunhofer-repdose.de)
  • Author:
    S.Escher et al.
  • Doc type:
    One pager
  • Downloads
    4425
Sound oral to inhalation extrapolation factors (EFs) for human health risk assessment

Introduction • Route to Route extrapolation (R2R) is required if no in vivo data on the appropriate route are available• R2R needs to be performed in a case by case approach for the individual…
  • Author:
    M.Batke et al.
  • Doc type:
    One Pager
  • Downloads
    4504
Assessment factors in human health risk assessment and their associated level of safety

Abstract Human health risk assessment of chemicals requires solid information on adverse effects after long-term exposure. Because of ethical considerations, human data or even long-term studies…
  • Author:
    S. Escher et al.
  • Doc type:
    Poster
  • Downloads
    4475
Route to Route Extrapolation Factors for Regulatory Risk Assessment – a Probabilistic Approach

Introduction EUROTOX 2014, 7th – 10th September 2014, Edinburgh International Conference Centre In human risk assessment any relevant exposure route (oral, inhalation and dermal) has to be…
  • Author:
    K. Schröder et al.
  • Doc type:
    One Pager
  • Downloads
    4986
Update of time extrapolation factors for risk assessment –the benefit of combined databases and probabilistic analyses

Introduction In regulatory risk assessment, extrapolation factors (EFs) are used to extrapolate from experimental conditions (animal studies) to human exposure.Time extrapolation: a short time study…
  • Author:
    S. Escher et al.
  • Doc type:
    One pager
  • Downloads
    4388
Time extrapolation factors for risk assessment: are group specific extrapolation factors possible? (eTOXV)

Abstract In risk assessment time extrapolationfactors (EFs) are used when a short time study is available, but chronic exposure needs to be considered.Probabilistic analyses are needed to…
  • Author:
    S. Escher et al.
  • Doc type:
    One pager
  • Downloads
    4588
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